Growth hormone-releasing hormone or somatocrinin is a releasing hormone specifically for growth hormone. In particular, it is a peptide consisting of 44 amino acids and is produced in the arcuate nucleus of the hypothalamus. The arcuate nucleus is a cluster of neurons in the mediobasal hypothalamus. Its main function is to aid in multiple physiological and neuroendocrine functions. Believe it or not, the first signs of growth hormone-releasing hormone or GHRH for short is between eighteen and twenty-nine weeks of the gestational period of pregnancy.
Overall, the main goal of GHRH is to stimulate growth hormones in the body. This is done by stimulating the GHRH receptor. The GHRH is then released in a steady pulsating rhythm this causes your growth hormone to be released in the same sense. It helps with things like postnatal growth, regulation of proteins, carbs, and lipid metabolism, as well as bone growth.
In many cases, the release and use of GHRH are actually inhibited by something known as somatostatin, or growth hormone inhibiting hormone. This mechanism is typically in place to ensure your body stays within balance but in rare cases, it can actually cause issues. This is where peptides such as CJC 1295 with DAC comes into play as it can essentially block somatostatin from reducing the amount of GHRH released to your body.
What Is CJC 1295?
CJC 1295 with DAC was developed by ConjuChem Biotechnologies, and the DAC at the end of the peptide is actually an acronym for drug affinity complex. In any sense, CJC 1295 DAC is a synthetic analog of growth hormone-releasing hormone also called growth hormone-releasing factor. This makes it a growth hormone secretagogue. What does that mean? It means that CJC 1295 with DAC aids in the secretion of growth hormone in the body.
It works by increasing IGF 1 as well as plasma growth hormone. Ever heard of the term bioconjugation? This is a chemical strategy that actually forms a stable bond between two molecules. Why is this important? Because CJC 1295 with DAC is able to extend the half-life and bioavailability of growth hormone-releasing hormone 1 – 29 because of this process.
In most cases, CJC 1295 with DAC is used for growth hormone deficiency. However, it has also been looked at as a treatment for lipodystrophy. This is a condition where the body is unable to maintain nor produce healthy fat tissue.
Application: Synthetic analogue of GHRH
Molecular Weight: 3367.954 g·MOL
Chemical Formula: C159H258N46O45
Chemical Name: L-Tyrosyl-D-alanyl-L-alpha-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-glutaminyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-L-alanyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-isoleucyl-L-leucyl-L-seryl-L-argininamide
Synonyms: Mod GRF(1-29), CJC-1295 W/O DAC. CJC-1295 Acetate
Storage: Minimize open air exposure, store in a cool, dry place.
Stability: 2 years
Solubility: Soluble to water at rate of 0.1mg/mL
Physical Form: fine powder in glass vial
Specifications: 2mg vial